Genome editing enables scientists to make precise changes to DNA, enhancing our understanding of gene function and facilitating the development of novel disease treatments. Genome editing CROs (Contract Research Organizations) play a pivotal role in supporting these advancements by offering specialized services to researchers and biotech companies. This technology allows for the introduction, deletion, or correction of DNA sequences across various cell types and organisms.
Here are 10 of the top genome editing CROs in North America in 2025. These DNA editing companies provide advanced solutions tailored for applications including drug discovery, functional genomics, and preclinical studies.
Here are 10 of the top genome editing CROs in North America:
Based in Milpitas, California, Applied StemCell is renowned for its expertise in advancing gene modification and stem cell innovation. The company provides customized solutions for drug discovery, bioprocessing, and preclinical applications. They specialize in generating cell lines for bioassays, creating physiologically relevant animal models of human diseases, and developing patient-specific cell models for personalized medicine. Additionally, ASC offers targeted genome editing using advanced CRISPR-Cas9 systems to ensure precise modifications.
Located in Mountain View, California, Cellecta is a leader in functional genomics and drug target discovery. Their expertise lies in pooled lentiviral shRNA and CRISPR libraries, providing comprehensive genetic screening solutions. The company also offers high-throughput library screening and next-generation sequencing (NGS) for detailed biomarker discovery. Cellecta’s services extend to creating isogenic cell lines and stable cDNA and CRISPR constructs, empowering researchers with tools for precision genomic research.
Integrated DNA Technologies (IDT)
Headquartered in Coralville, Iowa, IDT is globally recognized for its synthetic DNA and RNA products. The company provides high-quality CRISPR guide RNAs and genome editing kits designed to optimize precision in editing experiments. Researchers benefit from IDT’s custom DNA synthesis services, which include ultramer DNA oligos and gene fragments tailored to specific experimental needs. Their robust quality control measures and technical expertise make IDT a preferred partner for genome editing projects.
Horizon Discovery Based in Cambridge, Massachusetts, Horizon Discovery specializes in providing gene editing and gene modulation solutions. The company utilizes CRISPR-Cas9 and RNAi platforms to develop genetically engineered cell lines for drug discovery and functional genomic studies. Following its acquisition by PerkinElmer (now Revvity, Inc.), Horizon’s capabilities have expanded to include advanced screening technologies and gene editing solutions for precision medicine and therapeutic development.
GenScript ProBio
Based in Piscataway, New Jersey, GenScript ProBio is a leading provider of genome editing and biologics development services. The company’s expertise encompasses CRISPR and TALENs technologies for precise gene modification. GenScript ProBio supports clients through custom cell line development, plasmid DNA construction, and viral vector production. Their integrated solutions also include gene and cell therapy services, making them a versatile partner for both academic and industrial clients.
LocLocated in Monmouth Junction, New Jersey, Synbio Technologies leverages its proprietary "Synotype" platform to provide high-precision genome editing solutions. Their services include DNA synthesis, CRISPR/Cas9 editing, and pharmacogenomic research. Synbio Technologies collaborates with clients to design and implement complex genome editing strategies, facilitating advancements in synthetic biology and precision medicine. Their streamlined workflows and innovative platforms enable rapid translation of research into actionable results.
Situated in Lexington, Kentucky, Hera Biolabs is a preclinical CRO known for its expertise in gene editing and advanced animal models. The company’s offerings include proprietary cell line modification technologies and in vivo oncology models using genetically engineered rats. Hera’s services support drug development pipelines by enabling researchers to study complex disease pathways. Their portfolio also includes in vitro cell engineering for toxicology and pharmacology studies.
Headquartered in Wilmington, Massachusetts, Charles River is a global leader in preclinical research services. The company offers a range of genome editing capabilities, including CRISPR-mediated modifications for creating disease models. With a strong foundation in animal model development, Charles River supports translational research through advanced gene editing, enabling scientists to study complex human diseases in preclinical settings. Their global reach and comprehensive service portfolio make them a trusted partner for pharmaceutical and biotech companies.
Sangamo Therapeutics Based in Brisbane, California, Sangamo Therapeutics is a pioneer in genome editing and gene therapy development. Their proprietary zinc finger nuclease (ZFN) technology offers a precise alternative to CRISPR for therapeutic applications. Sangamo specializes in developing treatments for rare diseases, leveraging their genome editing expertise to create innovative therapies. Collaborations with leading biotech firms further enhance their contributions to advancing genomic medicine.
Editas MedicineLocated in Cambridge, Massachusetts, Editas Medicine is at the forefront of CRISPR-based genome editing. The company’s focus is on developing therapies for genetic disorders by targeting disease-causing mutations. Editas collaborates with academic and industry partners to advance preclinical development and therapeutic research. Their expertise in CRISPR technology positions them as a leader in translating genomic science into life-changing treatments.
Lab Management Software for Genome Editing CROs: Scispot
Scispot has emerged as an essential digital platform for genome editing CROs, transforming how modern biotech companies manage their workflows. It provides a centralized platform that integrates data management, research project tracking, inventory control, and collaboration tools. Scispot’s capabilities extend beyond traditional ELNs and LIMS, offering automation and customization to meet the unique needs of genome editing labs.
With Scispot, CROs can:
- Streamline Genome Editing Workflows: Automate routine tasks, track CRISPR experiments, and manage sample libraries.
- Enhance Data Integrity: Maintain complete audit trails and ensure compliance with regulatory standards.
- Enable Seamless Integrations: Connect with tools like Jupyter notebooks, external databases, and lab instruments for a cohesive research ecosystem.
Scispot empowers genome editing CROs to focus on innovation by reducing operational inefficiencies. Request a demo today to see how Scispot can elevate your lab’s performance.
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